exRNAdisease

Entry Detail

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General Information

Database ID: exR0428820 RNA Name: ACTN1 RNA Type: mRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 68874143 End Site(bp): 68979440 External Links: ENSG00000072110

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SLCO3A1 chr15 91853708 92172435 + ATP5F1B chr12 56638175 56645984 - MT-CO2 chrMT 7586 8269 + ZNF865 chr19 55605405 55617269 + DPM2 chr9 127935099 127938484 - G3BP1 chr5 151771045 151812785 + ACTN3 chr11 66546395 66563334 + VAT1 chr17 43014607 43025123 - HMGN1 chr21 39342315 39349647 - SUPT16H chr14 21351476 21384019 - PLPP3 chr1 56494761 56645301 - ERG28 chr14 75649791 75660876 - PKM chr15 72199029 72231822 - SPIN2B chrX 57118551 57121546 - NPC2 chr14 74476192 74494177 - PFKL chr21 44300051 44327376 + FYN chr6 111660332 111873452 - FARP2 chr2 241356285 241494841 + TRAF7 chr16 2155698 2178129 + AC245033.1 chr15 82536788 82573194 - SEC11A chr15 84669538 84716460 - HLA-B chr6 31269491 31357188 - DGCR8 chr22 20080232 20111877 + CHTF8 chr16 69118010 69132578 - ITFG2 chr12 2812622 2859791 + POLL chr10 101578882 101588270 - POLB chr8 42338454 42371808 + ROCK1 chr18 20946906 21111813 - CNOT1 chr16 58519951 58629885 - PITPNA chr17 1517718 1562792 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-367-3p chr4 112647877 112647898 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC245033.4 chr15 82533175 82540008 - BX284668.5 chr1 16887577 16889706 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.