exRNAdisease

Entry Detail

---



General Information

Database ID: exR0428822 RNA Name: ACTN4 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 38647649 End Site(bp): 38731589 External Links: ENSG00000130402

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NUP58 chr13 25301556 25349800 + ID1 chr20 31605283 31606515 + SAPCD1 chr6 31762996 31764851 + SNRNP200 chr2 96274338 96321271 - HSPA1A chr6 31815543 31817946 + MAN1C1 chr1 25617468 25786207 + IREB2 chr15 78437431 78501453 + CIB2 chr15 78104606 78131535 - CRNKL1 chr20 20034368 20056046 - TMEM158 chr3 45224466 45226287 - AC020915.5 chr19 58228914 58315183 + GCNT1 chr9 76419850 76651203 + ATIC chr2 215311956 215349773 + VAPA chr18 9914002 9960021 + YWHAQ chr2 9583967 9630997 - CHD9 chr16 53055033 53329150 + LRRD1 chr7 92141643 92179531 - RAD23B chr9 107283137 107332192 + CFL1 chr11 65823022 65862026 - STX10 chr19 13144058 13150383 - PRRC2B chr9 131373636 131500197 + MTRNR2L8 chr11 10507894 10509186 - HNRNPA2B1 chr7 26173057 26201529 - BSPRY chr9 113349541 113371233 + ZFHX4 chr8 76681239 76867281 + PTPN6 chr12 6946468 6961316 + SET chr9 128683424 128696400 + NEDD8 chr14 24216857 24232367 - PHLDB3 chr19 43474954 43504935 - PKM chr15 72199029 72231822 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-138-5p chr16 56858527 56858549 + hsa-miR-185-5p chr22 20033153 20033174 + hsa-miR-296-5p chr20 58817661 58817681 - hsa-miR-654-5p chr14 101040234 101040255 + hsa-miR-423-5p chr17 30117095 30117117 + hsa-miR-483-5p chr11 2134181 2134202 - hsa-miR-1286 chr22 20249145 20249165 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010997.3 chr10 75279726 75401246 - AC016876.2 chr17 7581964 7584086 - AC026304.1 chr3 143000907 143001467 - AC132217.1 chr11 2129121 2129964 - AC245014.3 chr1 145281116 145281462 + AC245033.4 chr15 82533175 82540008 - AD000090.1 chr19 35557956 35581954 + AC008731.1 chr16 24803451 24819739 - AC020915.1 chr19 58278966 58315197 + AC093734.1 chr7 1508655 1509427 - AC135178.2 chr17 8318088 8318712 - AL355075.4 chr14 20343048 20343685 - GHRLOS chr3 10285754 10294903 + LIMD1-AS1 chr3 45676369 45689200 - RMRP chr9 35657751 35658018 - SLC9A3-AS1 chr5 473236 480884 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.