exRNAdisease

Entry Detail

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General Information

Database ID: exR0428826 RNA Name: ACTR2 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 65227753 End Site(bp): 65271253 External Links: ENSG00000138071

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TBPL1 chr6 133952170 133990432 + LEPROT chr1 65420587 65436007 + SHMT2 chr12 57229573 57234935 + DDX10 chr11 108665069 108940927 + VASH2 chr1 212950520 212992037 + FUS chr16 31180110 31194871 + FAAP100 chr17 81539885 81553961 - KIAA0355 chr19 34254552 34355571 + WASF2 chr1 27404230 27490167 - TUBA3D chr2 131476119 131482934 + UBA52 chr19 18571730 18577550 + SURF6 chr9 133328776 133336188 - AMOT chrX 112774503 112840815 - RBM47 chr4 40423267 40630875 - TBC1D7 chr6 13266542 13328583 - GLS chr2 190880821 190965552 + PRMT5 chr14 22920525 22929408 - IGF2 chr11 2129112 2141238 - GZF1 chr20 23362182 23373062 + UCHL5 chr1 193012250 193060080 - VTA1 chr6 142147162 142224685 + MXI1 chr10 110207605 110287365 + FRMD8 chr11 65386621 65413525 + RTN3 chr11 63681446 63759891 + KPNA1 chr3 122421902 122514945 - AL035078.4 chr11 31812391 32104665 + MTRNR2L12 chr3 96617188 96618236 - RAC2 chr22 37225270 37244448 - RBM8A chr1 145917714 145927678 - ATP9B chr18 79069285 79378287 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC068831.7 chr15 91022766 91023200 + AC138761.1 chr17 22266395 22288301 + LINC01018 chr5 6582136 6600288 + LINC01641 chr1 227393554 227431035 + OIP5-AS1 chr15 41283990 41309737 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.