exRNAdisease

Entry Detail

---



General Information

Database ID: exR0428835 RNA Name: ACVR1B RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 51951699 End Site(bp): 51997078 External Links: ENSG00000135503

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HIBADH chr7 27525442 27662883 - LRRC42 chr1 53946085 53968168 + SNURF chr15 24954986 24977850 + RPL5 chr1 92832013 92841924 + WDR62 chr19 36054881 36105108 + RANBP2 chr2 108719482 108785809 + SLC7A6 chr16 68264516 68301823 + RPL18 chr19 48615328 48619184 - C9orf64 chr9 83938311 83956986 - ST6GAL1 chr3 186930502 187078553 + PPFIA4 chr1 203026498 203078740 + ZNF592 chr15 84748592 84806445 + TSPAN6 chrX 100627108 100639991 - MFGE8 chr15 88898683 88913381 - BAZ2A chr12 56595596 56636816 - DGAT1 chr8 144314584 144326910 - FZD3 chr8 28494205 28574267 + SMG5 chr1 156249224 156282825 - NMT1 chr17 45051610 45109016 + SETD2 chr3 47016429 47163967 - HACD3 chr15 65530418 65578349 + TAOK2 chr16 29973868 29992261 + CNPY3 chr6 42929192 42939294 + ABCB6 chr2 219209772 219218994 - RPL26 chr17 8377516 8383213 - DUSP3 chr17 43766125 43778977 - SYNGR2 chr17 78168558 78173527 + SSBP4 chr19 18418864 18434562 + AC010422.3 chr19 12643831 12648397 - PCNT chr21 46324141 46445769 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-7-5p chr19 4770700 4770723 + hsa-miR-143-3p chr5 149428978 149428998 + hsa-miR-9-5p chr5 88666902 88666924 - hsa-miR-136-5p chr14 100884716 100884738 + hsa-miR-185-5p chr22 20033153 20033174 + hsa-miR-342-3p chr14 100109715 100109737 + hsa-miR-769-5p chr19 46018961 46018982 + hsa-miR-541-3p chr14 101064548 101064569 + hsa-miR-760 chr1 93846880 93846899 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC139149.1 chr17 81514047 81527776 + AD000090.1 chr19 35557956 35581954 + AC135178.2 chr17 8318088 8318712 - DANCR chr4 52712404 52720351 + NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.