exRNAdisease

Entry Detail

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General Information

Database ID: exR0428838 RNA Name: ACVR2B RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 38453890 End Site(bp): 38493142 External Links: ENSG00000114739

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SF3A3 chr1 37956975 37990075 - LSM4 chr19 18306230 18323274 - DDX17 chr22 38483438 38507660 - MTCH1 chr6 36968141 36986298 - BCL6 chr3 187721377 187745725 - TCOF1 chr5 150357629 150400308 + LZTS2 chr10 100996618 101007836 + PACSIN2 chr22 42835412 43015149 - CBY1 chr22 38656636 38673854 + ZDBF2 chr2 206274663 206314427 + UNC45A chr15 90930180 90954093 + FAM111B chr11 59107185 59127412 + UBE3B chr12 109477402 109536705 + DNAAF2 chr14 49625174 49635230 - GPAM chr10 112149865 112215377 - CHRFAM7A chr15 30357766 30393849 - SORD chr15 45023181 45077185 + HSPA5 chr9 125234853 125241343 - MT-CO3 chrMT 9207 9990 + TBC1D15 chr12 71839707 71927248 + MYO7A chr11 77128246 77215241 + TUBA1B chr12 49127782 49131397 - HNRNPAB chr5 178204533 178211163 + MRPL12 chr17 81703367 81707517 + SNRPN chr15 24823637 24978723 + AL138752.2 chr9 37588413 38068687 - NT5DC2 chr3 52524385 52535054 - ISOC1 chr5 129094749 129114028 + SLC25A17 chr22 40769630 40819399 - CRMP1 chr4 5748084 5893086 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-221-3p chrX 45746180 45746202 - hsa-miR-423-5p chr17 30117095 30117117 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC090948.2 chr3 16339308 16339871 + AD000090.1 chr19 35557956 35581954 + LINC01578 chr15 92819540 92899701 + LINC02035 chr3 122886941 122892416 + NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.