exRNAdisease

Entry Detail

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General Information

Database ID: exR0428840 RNA Name: ACY1 RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 51983340 End Site(bp): 51989197 External Links: ENSG00000243989

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand INVS chr9 100099243 100302175 + PPP2R5E chr14 63371364 63543377 - SRSF1 chr17 58000919 58007346 - ANP32A chr15 68778535 68820897 - KDELR2 chr7 6445953 6484190 - OAS2 chr12 112978395 113011723 + ILF3 chr19 10654261 10692417 + SLC25A3 chr12 98593591 98606379 + ABCG2 chr4 88090150 88231628 - MAPK3 chr16 30114105 30123506 - TUBA1B chr12 49127782 49131397 - NEDD8 chr14 24216857 24232367 - ABHD14A-ACY1 chr3 51974706 51989183 + LASP1 chr17 38869859 38921770 + HERC1 chr15 63608618 63833948 - LRIG3 chr12 58872149 58920522 - TPI1 chr12 6867119 6870948 + ZNF623 chr8 143636013 143656418 + UBC chr12 124911604 124917368 - RPS3 chr11 75399515 75422280 + RBM38 chr20 57391396 57409333 + UCKL1 chr20 63939829 63956416 - PPTC7 chr12 110533245 110583318 - TRIM28 chr19 58544064 58550722 + RPLP0 chr12 120196699 120201235 - PABPN1 chr14 23321289 23326185 + GANAB chr11 62624826 62646726 - PLAT chr8 42174718 42207676 - TMEM184B chr22 38219291 38273010 - GNL3 chr3 52681156 52694497 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-625-5p chr14 65471116 65471136 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + DANCR chr4 52712404 52720351 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.