exRNAdisease

Entry Detail

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General Information

Database ID: exR0428847 RNA Name: ADAM10 RNA Type: mRNA Chromosome: chr15 Starnd: - Coordinate: Start Site(bp): 58588809 End Site(bp): 58749791 External Links: ENSG00000137845

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RPS11 chr19 49496365 49499708 + THUMPD3 chr3 9362971 9386791 + ATXN3 chr14 92044496 92106621 - NUDT21 chr16 56429133 56452199 - MORF4L1 chr15 78810487 78898139 + RPS24 chr10 78033760 78056813 + SMARCC1 chr3 47585269 47782106 - YY1 chr14 100238298 100282788 + RB1CC1 chr8 52622458 52745843 - SPATS2L chr2 200305881 200482264 + MAPK9 chr5 180233143 180292099 - RFLNA chr12 123973241 124316024 + TCTN3 chr10 95663396 95694143 - RPL13 chr16 89560657 89566828 + MRPL30 chr2 99181152 99199561 + METTL2B chr7 128476729 128506602 + MPZL1 chr1 167721192 167791919 + OSBP chr11 59574398 59615774 - PBX1 chr1 164555584 164899296 + TAB2 chr6 149218641 149411613 + RBM42 chr19 35629030 35637686 + WBP11 chr12 14784582 14803486 - TMEM189 chr20 50118254 50153734 - TRIM28 chr19 58544064 58550722 + GNAI3 chr1 109548615 109600195 + ANXA6 chr5 151100706 151157785 - XRCC6 chr22 41621119 41664048 + PGM3 chr6 83161150 83193936 - ACTN4 chr19 38647649 38731589 + E2F2 chr1 23506438 23531233 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-1248 chr3 186786675 186786701 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL096870.2 chr14 24209646 24215987 - AC068790.8 chr12 123973215 124088594 + AL645465.1 chr1 244375100 244409592 - FGD5-AS1 chr3 14920347 14948424 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.