exRNAdisease

Entry Detail

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General Information

Database ID: exR0428849 RNA Name: ADAM15 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 155050566 End Site(bp): 155062775 External Links: ENSG00000143537

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NNT chr5 43602692 43707405 + PCSK1N chrX 48831096 48835610 - RBM26 chr13 79311824 79406477 - AC096887.1 chr3 52969119 53099453 - DSG2 chr18 31498177 31549008 + NR3C1 chr5 143277931 143435512 - SF3A2 chr19 2236824 2248655 + MKI67 chr10 128096659 128126423 - HDHD5 chr22 17137511 17165287 - VAMP7 chrX 155881345 155943769 + CBFB chr16 67028984 67101058 + DYNLL2 chr17 58083419 58095542 + KIFC1 chr6 33391823 33409896 + SIGMAR1 chr9 34634722 34637809 - MTRNR2L12 chr3 96617188 96618236 - CNOT9 chr2 218568580 218597080 + OTUD4 chr4 145110838 145180589 - ATG4B chr2 241637213 241673857 + WNK1 chr12 752579 911452 + LTBP1 chr2 32946953 33399509 + MTHFD1 chr14 64388031 64463457 + ALDOA chr16 30064164 30070457 + APEX1 chr14 20455191 20457772 + TNRC18 chr7 5306790 5425414 - HK1 chr10 69269984 69401884 + MARCKS chr6 113857345 113863475 + SETD6 chr16 58515479 58521181 + PAX9 chr14 36657568 36679362 + NEK6 chr9 124257606 124353307 + PCYOX1L chr5 149358037 149369653 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.