exRNAdisease

Entry Detail

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General Information

Database ID: exR0428850 RNA Name: ADAM17 RNA Type: mRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 9488486 End Site(bp): 9556732 External Links: ENSG00000151694

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ITM2C chr2 230864639 230879248 + HUNK chr21 31873020 32044633 + TPGS2 chr18 36777647 36829216 - MOCS3 chr20 50958818 50963929 + ESCO2 chr8 27771949 27812640 + COMMD1 chr2 61888724 62147247 + TMX1 chr14 51240162 51257655 + NACA chr12 56712427 56731628 - ELOVL5 chr6 53267398 53349179 - KHDRBS1 chr1 32013868 32060850 + PSMA2 chr7 42916861 42932185 - PTMA chr2 231706895 231713541 + GATAD1 chr7 92447482 92460075 + SLC30A9 chr4 41990502 42090461 + SUGP2 chr19 18990888 19034023 - CCT5 chr5 10249929 10266389 + RNF44 chr5 176526712 176538025 - ATP5MC3 chr2 175176258 175184607 - G6PC3 chr17 44070735 44076344 + ZSCAN30 chr18 35251058 35290245 - MDN1 chr6 89642498 89819794 - GSTP1 chr11 67583742 67586656 + MARCKSL1 chr1 32333839 32336233 - PSMD2 chr3 184299198 184309050 + XPO6 chr16 28097979 28211920 - EIF3A chr10 119033670 119080823 - AL136454.1 chr1 192716132 192716653 + PIK3CA chr3 179148114 179240093 + COL11A2 chr6 33162681 33192499 - ZNF24 chr18 35332227 35345482 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand BX284668.2 chr1 16870945 16883659 + LINC01783 chr1 16533886 16536172 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.