exRNAdisease

Entry Detail

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General Information

Database ID: exR0428882 RNA Name: ADAMTSL4 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 150549369 End Site(bp): 150560937 External Links: ENSG00000143382

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BAG6 chr6 31639028 31652705 - POLR2C chr16 57462660 57472009 + LMNA chr1 156082573 156140089 + EIF3L chr22 37848868 37889407 + NSD1 chr5 177133025 177300215 + ZIC2 chr13 99981784 99986765 + BST2 chr19 17402939 17405630 - NENF chr1 212432920 212446379 + TAF1D chr11 93729948 93784391 - URM1 chr9 128371361 128392016 + CNN2 chr19 1026586 1039068 + PABPC1 chr8 100685816 100722809 - ORC6 chr16 46689643 46698394 + ZNF678 chr1 227563543 227677443 + NFS1 chr20 35668052 35699355 - FLNA chrX 154348524 154374638 - VPS4A chr16 69311350 69326939 + TIAL1 chr10 119571802 119597029 - SMARCD2 chr17 63832081 63843065 - ZDHHC18 chr1 26826688 26857604 + UBE2V2 chr8 48008415 48064708 + ANKFY1 chr17 4163821 4263995 - FAR1 chr11 13668668 13732346 + RANGAP1 chr22 41245611 41286251 - SH3KBP1 chrX 19533977 19887600 - SFPQ chr1 35176378 35193145 - EIF4H chr7 74174245 74197101 + ARF4 chr3 57571363 57598220 - LIN28B chr6 104936616 105083332 + IGF2 chr11 2129112 2141238 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC132217.1 chr11 2129121 2129964 - AP001372.2 chr11 74493366 74498533 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.