exRNAdisease

Entry Detail

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General Information

Database ID: exR0428897 RNA Name: ADCY3 RNA Type: mRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 24819169 End Site(bp): 24919839 External Links: ENSG00000138031

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand COL4A5 chrX 108439844 108697545 + GPC3 chrX 133535745 133985594 - ERCC2 chr19 45349837 45370918 - HNRNPL chr19 38836388 38852347 - GMPR chr6 16238587 16295549 + MED12 chrX 71118556 71142454 + PIEZO2 chr18 10666483 11148762 - PIP5K1C chr19 3630183 3700479 - MTRR chr5 7851186 7906025 + IMP4 chr2 130342877 130347967 + PEX2 chr8 76980258 77001044 - RPL4 chr15 66498015 66524532 - CCDC47 chr17 63745255 63776351 - HIGD1A chr3 42784298 42804531 - CYTH1 chr17 78674048 78782297 - MSC chr8 71841549 71844468 - LCOR chr10 96832282 96995959 + KIF1A chr2 240713761 240821036 - SESN3 chr11 95165513 95232541 - RHOC chr1 112701106 112707434 - WDR81 chr17 1716523 1738599 + FAM8A1 chr6 17600302 17611715 + RAN chr12 130872037 130877678 + ANO8 chr19 17323223 17334855 - AKT2 chr19 40230317 40285536 - POTEF chr2 130073535 130129222 - GNB1 chr1 1785285 1891117 - PIH1D1 chr19 49446298 49453497 - NFE2L1 chr17 48048329 48061545 + AL049629.2 chr11 33698261 33722467 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-367-3p chr4 112647877 112647898 - hsa-miR-92b-3p chr1 155195237 155195258 + hsa-miR-155-3p chr21 25574022 25574043 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC073062.1 chr2 13537673 13609168 + AC099329.1 chr3 42785087 42852428 - AL160408.3 chr1 234669523 234696153 - LINC01866 chr2 16970034 16974497 + MEF2C-AS1 chr5 88883328 89466398 + MIR155HG chr21 25561909 25575168 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.