exRNAdisease

Entry Detail

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General Information

Database ID: exR0428903 RNA Name: ADCY9 RNA Type: mRNA Chromosome: chr16 Starnd: - Coordinate: Start Site(bp): 3953387 End Site(bp): 4116442 External Links: ENSG00000162104

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CHMP1A chr16 89644435 89657721 - MAN2A1 chr5 109689366 109869625 + CHMP2A chr19 58551566 58555105 - CXXC1 chr18 50282343 50288304 - C11orf24 chr11 68261338 68272001 - RC3H2 chr9 122844556 122905359 - LRFN3 chr19 35935358 35946624 + PPIB chr15 64155812 64163205 - BRWD1 chr21 39184176 39321559 - RRP7A chr22 42508344 42519796 - SPTAN1 chr9 128552558 128633662 + SF3A2 chr19 2236824 2248655 + TBCB chr19 36114289 36125947 + INTS11 chr1 1311585 1324691 - PLCG2 chr16 81739097 81962685 + DDX39B chr6 31530219 31542448 - HUWE1 chrX 53532096 53686728 - TAF5L chr1 229593111 229626047 - DPM2 chr9 127935099 127938484 - POLG chr15 89305198 89334861 - UBE2M chr19 58555712 58558954 - JMJD8 chr16 681670 684528 - LGR5 chr12 71439798 71586310 + AKT1 chr14 104769349 104795751 - MAN2C1 chr15 75355207 75368612 - HMBOX1 chr8 28890395 29064764 + PTPRF chr1 43525187 43623666 + PROB1 chr5 139390592 139395104 - MON1B chr16 77190835 77202398 + AMIGO3 chr3 49716829 49719684 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-25-3p chr7 100093571 100093592 - hsa-miR-33a-5p chr22 41900949 41900969 + hsa-miR-147a chr9 120244985 120245004 - hsa-miR-218-5p chr5 168768211 168768231 - hsa-miR-367-3p chr4 112647877 112647898 - hsa-miR-338-3p chr17 81125887 81125908 - hsa-miR-92b-3p chr1 155195237 155195258 + hsa-miR-33b-5p chr17 17813897 17813916 - hsa-miR-541-3p chr14 101064548 101064569 + hsa-miR-147b-3p chr15 45433098 45433118 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand LINC00265 chr7 39733430 39793092 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.