exRNAdisease

Entry Detail

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General Information

Database ID: exR0428906 RNA Name: ADD1 RNA Type: mRNA Chromosome: chr4 Starnd: + Coordinate: Start Site(bp): 2843857 End Site(bp): 2930076 External Links: ENSG00000087274

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HIRA chr22 19330698 19447450 - DDX17 chr22 38483438 38507660 - HNRNPAB chr5 178204533 178211163 + ENO1 chr1 8861000 8879190 - MFSD14A chr1 100038095 100083377 + RABGAP1L chr1 174159410 174995308 + MARCKSL1 chr1 32333839 32336233 - MTERF4 chr2 241072169 241102332 - EIF3L chr22 37848868 37889407 + CDC123 chr10 12195965 12250589 + RPS10 chr6 34417454 34426069 - PDHA2 chr4 95840093 95841464 + RPL9 chr4 39452521 39458949 - NPM1 chr5 171387116 171411137 + IFI44L chr1 78619922 78646145 + SAMD11 chr1 923928 944581 + B2M chr15 44711487 44718877 + POLE chr12 132623753 132687376 - HNRNPUL2 chr11 62712630 62727457 - ELOC chr8 73939169 73972287 - RGL2 chr6 33291654 33298942 - BIRC2 chr11 102347211 102378670 + HLA-A chr6 29941260 29945884 + RPL4 chr15 66498015 66524532 - RPS3 chr11 75399515 75422280 + LPCAT3 chr12 6976185 7018477 - CARHSP1 chr16 8852942 8869012 - CAPN15 chr16 527712 554636 + CLN6 chr15 68206992 68257211 - RPS27A chr2 55231903 55235853 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-184 chr15 79209840 79209861 + hsa-miR-654-5p chr14 101040234 101040255 + hsa-miR-193a-5p chr17 31560016 31560037 + hsa-miR-361-3p chrX 85903641 85903663 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand ACVR2B-AS1 chr3 38451027 38454820 - AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AC009163.4 chr16 75458252 75460017 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.