exRNAdisease

Entry Detail

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General Information

Database ID: exR0428932 RNA Name: ADGRL1 RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 14147743 End Site(bp): 14206187 External Links: ENSG00000072071

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AKT2 chr19 40230317 40285536 - NCLN chr19 3185563 3209575 + FOXO3 chr6 108559835 108684774 + EPB41L5 chr2 120013077 120179119 + MT-ND4 chrMT 10760 12137 + FAM98C chr19 38403135 38409088 + TSTA3 chr8 143612618 143618048 - HNRNPA2B1 chr7 26173057 26201529 - ACACA chr17 37084992 37406836 - SPHK2 chr19 48619291 48630717 + KIAA0930 chr22 45190338 45240769 - HMGA1 chr6 34236873 34246231 + DDIT4L chr4 100185870 100190782 - P4HTM chr3 48989889 49007153 + CBL chr11 119206298 119313926 + OTUD7A chr15 31475398 31870789 - DPYSL3 chr5 147390808 147510068 - SRRM3 chr7 76201896 76287288 + MTRNR2L8 chr11 10507894 10509186 - EIF3K chr19 38619082 38636955 + WDR82 chr3 52254434 52288020 - SYMPK chr19 45815410 45863194 - NPC2 chr14 74476192 74494177 - SELENOP chr5 42799880 42887392 - NUP62 chr19 49906825 49929763 - RPS11 chr19 49496365 49499708 + POLR3C chr1 145824088 145844402 + P3H4 chr17 41801947 41812604 - COL5A2 chr2 189031898 189225312 - PIP4P1 chr14 20457719 20461612 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-15a-5p chr13 50049167 50049188 - hsa-miR-185-5p chr22 20033153 20033174 + hsa-miR-423-5p chr17 30117095 30117117 + hsa-miR-541-3p chr14 101064548 101064569 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + BX284668.2 chr1 16870945 16883659 + MIR663AHG chr20 26167817 26251546 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.