exRNAdisease

Entry Detail

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General Information

Database ID: exR0428972 RNA Name: AEN RNA Type: mRNA Chromosome: chr15 Starnd: + Coordinate: Start Site(bp): 88621337 End Site(bp): 88632281 External Links: ENSG00000181026

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HSP90AA1 chr14 102080738 102139699 - PTEN chr10 87863625 87971930 + MAPK9 chr5 180233143 180292099 - PABPC1 chr8 100685816 100722809 - ITM2C chr2 230864639 230879248 + KAT7 chr17 49788681 49835026 + HCCS chrX 11111301 11123086 + MESD chr15 80946289 80989828 - PPP1CB chr2 28751640 28802940 + PEBP1 chr12 118136124 118145584 + STARD7 chr2 96184859 96208825 - YBX1 chr1 42682418 42703805 + MYL6 chr12 56158161 56163496 + STRN4 chr19 46719511 46746994 - AC006538.2 chr19 2717769 2740048 - APH1A chr1 150265399 150269580 - JUNB chr19 12791486 12793315 + TSR2 chrX 54440404 54448032 + PLK1 chr16 23677656 23690367 + MATK chr19 3777970 3802129 - CSDE1 chr1 114716913 114758676 - FKBP8 chr19 18531751 18544077 - TOR1A chr9 129812942 129824244 - R3HDM2 chr12 57253762 57431005 - GBE1 chr3 81489703 81761645 - IVD chr15 40405485 40435947 + GPBP1 chr5 57173948 57264679 + ZNF202 chr11 123723914 123741675 - HSPA4 chr5 133052013 133106449 + MDK chr11 46380756 46383837 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-24-3p chr9 95086064 95086085 + hsa-miR-27a-3p chr19 13836447 13836467 - hsa-miR-101-3p chr1 65058442 65058462 - hsa-miR-27b-3p chr9 95085505 95085525 + hsa-miR-513a-5p chrX 147213538 147213555 - hsa-miR-455-5p chr9 114209449 114209470 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC093827.4 chr4 86924630 86936202 - AD000090.1 chr19 35557956 35581954 + CCDC183-AS1 chr9 136803927 136808848 - LNCPRESS1 chr7 101299578 101301346 + NEAT1 chr11 65422774 65445540 + SNHG3 chr1 28505980 28510892 + XIST chrX 73820649 73852723 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.