exRNAdisease

Entry Detail

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General Information

Database ID: exR0428973 RNA Name: AFAP1 RNA Type: mRNA Chromosome: chr4 Starnd: - Coordinate: Start Site(bp): 7758714 End Site(bp): 7939926 External Links: ENSG00000196526

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RAPGEF1 chr9 131576770 131740074 - PGAM1 chr10 97426191 97433444 + RBX1 chr22 40951347 40973309 + ZNF462 chr9 106863166 107013634 + DKC1 chrX 154762742 154777689 + PA2G4 chr12 56104537 56113910 + NCL chr2 231453531 231483641 - LAMTOR2 chr1 156054782 156058506 + GAPDH chr12 6534512 6538374 + EXOSC4 chr8 144078648 144080648 + RPS14 chr5 150442635 150449739 - WDR46 chr6 33279108 33289247 - TCP1 chr6 159778498 159789703 - PITX2 chr4 110617423 110642123 - FNDC3A chr13 48975912 49209779 + PFN1 chr17 4945652 4949061 - FKBP1A chr20 1368978 1393172 - HS6ST1 chr2 128236716 128318868 - DTL chr1 212035553 212107400 + TNIK chr3 171058414 171460408 - GDAP1 chr8 74321130 74488872 + ACOX3 chr4 8366282 8440723 - YME1L1 chr10 27110112 27155266 - ERP29 chr12 112013348 112023449 + MT-CO1 chrMT 5904 7445 + PABPC4 chr1 39560816 39576790 - MT-ND2 chrMT 4470 5511 + BOD1 chr5 173607145 173616659 - NUCKS1 chr1 205712822 205750182 - SPG7 chr16 89490719 89557768 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-193a-3p chr17 31560050 31560071 + hsa-miR-485-5p chr14 101055427 101055448 + hsa-miR-193b-3p chr16 14304017 14304038 + hsa-miR-650 chr22 22822791 22822811 + hsa-miR-423-5p chr17 30117095 30117117 + hsa-miR-664b-5p chrX 154768596 154768619 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AL355987.4 chr9 136799223 136810042 + SNHG14 chr15 24978583 25420336 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.