exRNAdisease

Entry Detail

---



General Information

Database ID: exR0428976 RNA Name: AFDN RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 167826922 End Site(bp): 167972023 External Links: ENSG00000130396

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand WDR36 chr5 111091716 111130502 + AGO3 chr1 35930718 36072500 + TXNRD1 chr12 104215779 104350307 + TOMM34 chr20 44942130 44960397 - NFE2L1 chr17 48048329 48061545 + DDX5 chr17 64498254 64508199 - TMEM243 chr7 87196160 87220587 - PABPC3 chr13 25095868 25099254 + DHPS chr19 12675717 12681880 - CALU chr7 128739292 128773400 + NKTR chr3 42600655 42648735 + SON chr21 33543038 33577481 + MT-CO3 chrMT 9207 9990 + UVSSA chr4 1347208 1395989 + MYB chr6 135181308 135219173 + HOXB7 chr17 48607232 48633572 - ZNF395 chr8 28345590 28402701 - SREBF2 chr22 41833079 41907307 + KHSRP chr19 6413348 6424794 - RTEL1-TNFRSF6B chr20 63659300 63698684 + PANK3 chr5 168548495 168579368 - FDFT1 chr8 11795573 11839304 + TUBA1A chr12 49184795 49189080 - RINL chr19 38867830 38878275 - PPP1CA chr11 67398183 67421183 - SMC1A chrX 53374149 53422728 - ACTG1 chr17 81509971 81523847 - NIPSNAP1 chr22 29554808 29581327 - CYTH2 chr19 48469208 48482314 + ARHGDIB chr12 14942031 14961728 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-652-3p chrX 110055389 110055409 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011498.1 chr19 4457962 4471493 - AC067930.4 chr8 143573490 143577397 + AD000090.1 chr19 35557956 35581954 + AL162586.1 chr9 127816066 127822520 + AP005263.1 chr18 9102736 9254346 + LINC00205 chr21 45288050 45297806 + LINC01578 chr15 92819540 92899701 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.