exRNAdisease

Entry Detail

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General Information

Database ID: exR0428977 RNA Name: AFF1 RNA Type: mRNA Chromosome: chr4 Starnd: + Coordinate: Start Site(bp): 86935002 End Site(bp): 87141054 External Links: ENSG00000172493

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AP1G1 chr16 71729000 71809201 - TMBIM6 chr12 49707725 49764934 + UBALD2 chr17 76265348 76271298 + KIF1C chr17 4997950 5028401 + ERAL1 chr17 28855010 28861061 + HNRNPM chr19 8444767 8489114 + DUSP5 chr10 110497907 110511533 + VPS13A chr9 77177445 77421537 + RAB5C chr17 42124976 42155044 - RAVER2 chr1 64745095 64833232 + RSU1 chr10 16590611 16817463 - DNAJC5 chr20 63895126 63936031 + RHEB chr7 151466012 151520120 - TSR1 chr17 2322396 2336657 - CHD8 chr14 21385194 21456126 - UNC13D chr17 75827225 75844717 - MCM2 chr3 127598410 127622436 + RANBP2 chr2 108719482 108785809 + ACTG1 chr17 81509971 81523847 - PRDX6 chr1 173477330 173488815 + BAZ1B chr7 73440406 73522293 - ABI1 chr10 26746593 26861087 - KRAS chr12 25205246 25250936 - STRBP chr9 123109500 123268586 - CC2D1A chr19 13906201 13930879 + COPS8 chr2 237085882 237100474 + DEDD chr1 161120974 161132688 - SSRP1 chr11 57325986 57335892 - CASP8 chr2 201233443 201287711 + TMEM237 chr2 201620184 201643570 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC025181.2 chr5 32174471 32175272 + MAPKAPK5-AS1 chr12 111839764 111842902 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.