exRNAdisease

Entry Detail

---



General Information

Database ID: exR0428980 RNA Name: AFF4 RNA Type: mRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 132875395 End Site(bp): 132963634 External Links: ENSG00000072364

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CCDC6 chr10 59788747 59906556 - GAN chr16 81314966 81380198 + KCTD3 chr1 215567304 215621807 + MAPK14 chr6 36027677 36111236 + CDYL chr6 4706159 4955551 + KRAS chr12 25205246 25250936 - ANKHD1-EIF4EBP3 chr5 140401908 140549569 + ARFGEF3 chr6 138161939 138344663 + EIF3C chr16 28688558 28735730 + ENSA chr1 150600851 150629612 - UBA52 chr19 18571730 18577550 + FCHSD1 chr5 141639302 141651418 - BRK1 chr3 10115675 10127190 + AC048338.1 chr12 122207779 122266423 - GUCY1B1 chr4 155758992 155807774 + RPLP1 chr15 69452814 69456205 + SNRPA chr19 40750637 40765389 + MTX3 chr5 79976731 79991265 - KCNN1 chr19 17951293 18000080 + RHOG chr11 3826978 3840959 - TUBA1B chr12 49127782 49131397 - CSK chr15 74782057 74803198 + RHEB chr7 151466012 151520120 - NUCKS1 chr1 205712822 205750182 - DEPDC1 chr1 68474152 68497221 - EIF4EBP3 chr5 140547662 140549576 + SMARCC1 chr3 47585269 47782106 - HDHD2 chr18 47107408 47150500 - NET1 chr10 5412557 5459056 + HNRNPDL chr4 82422564 82430408 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-20a-5p chr13 91351072 91351094 + hsa-miR-33a-5p chr22 41900949 41900969 + hsa-miR-93-5p chr7 100093815 100093837 - hsa-miR-205-5p chr1 209432166 209432187 + hsa-miR-106b-5p chr7 100094043 100094063 - hsa-miR-299-3p chr14 101023832 101023853 + hsa-miR-519c-5p chr19 53686484 53686505 + hsa-miR-526a-5p chr19 53726928 53726949 + hsa-miR-33b-5p chr17 17813897 17813916 - hsa-miR-642a-5p chr19 45674943 45674964 + hsa-miR-423-5p chr17 30117095 30117117 + hsa-miR-519b-5p chr19 53695225 53695246 + hsa-miR-520c-5p chr19 53707468 53707489 + hsa-miR-518d-5p chr19 53734892 53734913 + hsa-miR-1321 chrX 85835832 85835849 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008105.3 chr17 45190931 45222222 - AC091564.7 chr11 6610883 6616594 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.