exRNAdisease

Entry Detail

---



General Information

Database ID: exR0428984 RNA Name: AFTPH RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 64524305 End Site(bp): 64593005 External Links: ENSG00000119844

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BID chr22 17734138 17774770 - YWHAQ chr2 9583967 9630997 - CLEC2D chr12 9664969 9699553 + NAP1L1 chr12 76036585 76084958 - DTYMK chr2 241675747 241686944 - TWSG1 chr18 9334767 9402420 + TUBA1B chr12 49127782 49131397 - LAMC1 chr1 183023420 183145592 + BIRC2 chr11 102347211 102378670 + CUL3 chr2 224470150 224585397 - PGK1 chrX 77910739 78129295 + HLA-A chr6 29941260 29945884 + HEXA chr15 72340919 72376476 - STRN4 chr19 46719511 46746994 - RPUSD4 chr11 126202096 126211692 - HLA-F chr6 29722775 29738528 + BRPF3 chr6 36196744 36232790 + CD48 chr1 160678746 160711831 - ATP5MG chr11 118401606 118431496 + LCP1 chr13 46125920 46211871 - ATP8B2 chr1 154325553 154351304 + NCL chr2 231453531 231483641 - AKIRIN2 chr6 87674860 87702233 - HNRNPU chr1 244840638 244864560 - HDAC2 chr6 113933028 114011308 - PHF20 chr20 35771974 35950370 + RPL32 chr3 12834485 12841582 - MRPL4 chr19 10251901 10260055 + RPL27 chr17 42998273 43002959 + YWHAH chr22 31944522 31957603 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand LINC01405 chr12 110934590 110959093 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.