exRNAdisease

Entry Detail

---



General Information

Database ID: exR0428985 RNA Name: AGA RNA Type: mRNA Chromosome: chr4 Starnd: - Coordinate: Start Site(bp): 177430774 End Site(bp): 177442437 External Links: ENSG00000038002

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANAPC4 chr4 25377213 25418498 + ATP6V1H chr8 53715543 53843558 - BTF3 chr5 73498408 73505635 + CAPN1 chr11 65180566 65212006 + CAT chr11 34438934 34472060 + CCDC169 chr13 36222008 36297840 - CCDC169-SOHLH2 chr13 36168794 36297842 - CHD8 chr14 21385194 21456126 - FADS2 chr11 61792980 61867354 + FAM107B chr10 14518557 14774897 - MCM2 chr3 127598410 127622436 + MRPL3 chr3 131462212 131502983 - MTRNR2L12 chr3 96617188 96618236 - PFN1 chr17 4945652 4949061 - PPM1A chr14 60245752 60299087 + PTGES3 chr12 56663341 56688408 - PUM3 chr9 2720469 2844095 - RPL13A chr19 49487554 49492308 + RPL27A chr11 8682788 8714759 + RPL5 chr1 92832013 92841924 + RPL8 chr8 144789765 144792587 - RPS20 chr8 56067295 56074581 - SPNS1 chr16 28974221 28984548 + SRGN chr10 69088103 69104805 + TAF7 chr5 141260225 141320784 - TMBIM6 chr12 49707725 49764934 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC109460.3 chr16 28974804 28990775 + LOH12CR2 chr12 12355406 12357067 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.