exRNAdisease

Entry Detail

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General Information

Database ID: exR0428986 RNA Name: AGAP1 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 235494043 End Site(bp): 236131800 External Links: ENSG00000157985

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand KAT2A chr17 42113111 42121367 - LIN54 chr4 82909973 83012926 - ENAH chr1 225486835 225653142 - OXSR1 chr3 38165089 38255484 + NCOR2 chr12 124324415 124567589 - LMAN2 chr5 177331567 177351668 - NFATC2IP chr16 28950807 28967097 + C14orf132 chr14 96039324 96093889 + HES6 chr2 238238267 238240662 - SELENOW chr19 47778585 47784686 + HDAC3 chr5 141620876 141636849 - CUL3 chr2 224470150 224585397 - RPUSD1 chr16 784974 788397 - SNX10 chr7 26291895 26374329 + CNOT1 chr16 58519951 58629885 - MEIS1 chr2 66433452 66573869 + GIGYF2 chr2 232697299 232860575 + TEX264 chr3 51662693 51704323 + KIF1A chr2 240713761 240821036 - RPS27A chr2 55231903 55235853 + GNAS chr20 58839718 58911192 + TRAIP chr3 49828601 49856574 - GDAP2 chr1 117863485 117929621 - DYNC1LI1 chr3 32525974 32570858 - SLX1A chr16 30193887 30197561 + LRBA chr4 150264435 151015727 - GAPDH chr12 6534512 6538374 + PSMD7 chr16 74296814 74306288 + SIPA1L2 chr1 232397965 232561558 - HMGA2 chr12 65824131 65966295 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022400.3 chr10 73674295 73730466 - AGAP1-IT1 chr2 235505751 235507566 + AGAP11 chr10 86970741 87010126 + AL136982.1 chr10 86992406 87010203 + NOP14-AS1 chr4 2934882 2961738 + SLX1A-SULT1A3 chr16 30193892 30204310 + TMEM147-AS1 chr19 35540738 35546029 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.