exRNAdisease

Entry Detail

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General Information

Database ID: exR0429006 RNA Name: AGO1 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 35869808 End Site(bp): 35930532 External Links: ENSG00000092847

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MT-ND4L chrMT 10470 10766 + ESPL1 chr12 53268299 53293638 + SAMD4B chr19 39342396 39385710 + CANX chr5 179678628 179731641 + NFATC2IP chr16 28950807 28967097 + LAMTOR1 chr11 72085895 72103297 - PSMD2 chr3 184299198 184309050 + AP1B1 chr22 29327680 29423179 - PJA2 chr5 109334713 109409974 - KDM4B chr19 4969113 5153598 + REC8 chr14 24171853 24180257 + PTMA chr2 231706895 231713541 + HLA-A chr6 29941260 29945884 + FTO chr16 53701692 54158512 + KRIT1 chr7 92198969 92246166 - DNMBP chr10 99875577 100009947 - AP002990.1 chr11 62559603 62591531 - RPL36AL chr14 49618530 49620626 - SMS chrX 21940709 21994837 + SPINT2 chr19 38244035 38292615 + KLHL36 chr16 84648511 84667686 + PANX1 chr11 94128841 94181968 + CALM1 chr14 90396502 90408268 + PRPF40A chr2 152651593 152717997 - AGO2 chr8 140520156 140635633 - NEURL4 chr17 7315628 7329393 - RPL32 chr3 12834485 12841582 - RPL8 chr8 144789765 144792587 - LCOR chr10 96832282 96995959 + SND1 chr7 127652194 128092609 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + AC007347.1 chr16 54033997 54054583 - AC022034.3 chr8 53394110 53484067 - LINC01641 chr1 227393554 227431035 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.