exRNAdisease

Entry Detail

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General Information

Database ID: exR0429007 RNA Name: AGO2 RNA Type: mRNA Chromosome: chr8 Starnd: - Coordinate: Start Site(bp): 140520156 End Site(bp): 140635633 External Links: ENSG00000123908

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RPL13 chr16 89560657 89566828 + SPECC1 chr17 20009344 20319026 + ENO1 chr1 8861000 8879190 - EIF2AK1 chr7 6022247 6059175 - RAB5B chr12 55973913 55996683 + PLXNB2 chr22 50274979 50307646 - LENG8 chr19 54448887 54462037 + HNRNPU chr1 244840638 244864560 - SMAD7 chr18 48919853 48952052 - BRIX1 chr5 34915677 34925996 + CD3EAP chr19 45406209 45410766 + PSMC3IP chr17 42572315 42577831 - CCDC137 chr17 81666737 81673904 + TSPYL1 chr6 116267760 116279903 - TIAL1 chr10 119571802 119597029 - AGO1 chr1 35869808 35930532 + GID8 chr20 62938147 62948475 + ERBB2 chr17 39687914 39730426 + TSPAN13 chr7 16753755 16784536 + RMDN3 chr15 40735884 40755851 - TFDP1 chr13 113584721 113641473 + PLXNA1 chr3 126988594 127037392 + PDLIM1 chr10 95237572 95291012 - MCC chr5 113022099 113488823 - RANBP9 chr6 13621498 13711835 - NPC1 chr18 23506184 23586506 - ILF3 chr19 10654261 10692417 + APRT chr16 88809339 88811937 - SMARCD2 chr17 63832081 63843065 - TCF4 chr18 55222185 55664787 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC068831.7 chr15 91022766 91023200 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.