exRNAdisease

Entry Detail

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General Information

Database ID: exR0429009 RNA Name: AGO4 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 35808016 End Site(bp): 35857890 External Links: ENSG00000134698

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADAM19 chr5 157395534 157575775 - MT1G chr16 56666731 56668065 - POLD2 chr7 44114681 44124358 - UBXN6 chr19 4444999 4457794 - RPLP2 chr11 809965 812880 + TATDN2 chr3 10248023 10281218 + PTGES2 chr9 128120693 128128462 - VAMP3 chr1 7771296 7781432 + CBFA2T2 chr20 33490075 33650036 + TMEM132A chr11 60924463 60937159 + MT-CO3 chrMT 9207 9990 + TRIM73 chr7 75395063 75410996 + SFPQ chr1 35176378 35193145 - PMEL chr12 55954105 55973317 - RPL37 chr5 40825262 40835222 - GATA2 chr3 128479427 128493201 - PTMA chr2 231706895 231713541 + SRGN chr10 69088103 69104805 + YBX1 chr1 42682418 42703805 + SLC38A2 chr12 46358188 46372773 - HNRNPF chr10 43385617 43409166 - ANKH chr5 14704800 14871778 - AGO3 chr1 35930718 36072500 + OSBPL8 chr12 76351797 76559809 - DDX5 chr17 64498254 64508199 - SDF4 chr1 1216908 1232067 - XPO1 chr2 61477849 61538626 - LGMN chr14 92703807 92748679 - ARL8B chr3 5122245 5180912 + GGCT chr7 30496621 30504841 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC124944.3 chr3 195900986 195903417 + NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.