exRNAdisease

Entry Detail

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General Information

Database ID: exR0429017 RNA Name: AGRN RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 1020120 End Site(bp): 1056118 External Links: ENSG00000188157

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCA2 chr9 137007234 137028922 - LDB1 chr10 102106489 102120368 - PPP1R14B chr11 64244479 64246943 - SAE1 chr19 47113274 47210636 + BTBD2 chr19 1985438 2034881 - ARFGAP2 chr11 47164299 47177125 - HAX1 chr1 154272589 154275875 + GPR153 chr1 6247353 6261098 - SHMT2 chr12 57229573 57234935 + INPPL1 chr11 72223701 72239147 + TSPAN4 chr11 842812 867116 + ZCCHC14 chr16 87406246 87493024 - CKAP5 chr11 46743048 46846308 - POP7 chr7 100706121 100707486 + PSMC5 chr17 63827152 63832026 + VPS26A chr10 69123512 69174412 + AP002990.1 chr11 62559603 62591531 - PAK6 chr15 40217428 40277487 + ARFGEF1 chr8 67173511 67343781 - TECR chr19 14517085 14565980 + TLN1 chr9 35696948 35732195 - CHD2 chr15 92900189 93027996 + TOE1 chr1 45340052 45343973 + STK11 chr19 1177558 1228431 + FGFRL1 chr4 1009936 1026898 + CYB5R3 chr22 42617840 42649392 - OTUD5 chrX 48922028 48958386 - EAF1 chr3 15427598 15450635 + EFTUD2 chr17 44849948 44899445 - DERA chr12 15911302 16037381 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-let-7a-5p chr9 94175962 94175983 + hsa-miR-184 chr15 79209840 79209861 + hsa-miR-654-5p chr14 101040234 101040255 + hsa-miR-541-3p chr14 101064548 101064569 + hsa-miR-5100 chr10 42997630 42997651 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002470.2 chr22 20979462 20998121 + AC005332.6 chr17 68126666 68129586 + AC079922.2 chr2 112641832 112645720 - AC114271.1 chr19 10333436 10336248 + AD000090.1 chr19 35557956 35581954 + AL031963.3 chr6 3068045 3068894 - AC079949.1 chr12 127142029 127146532 - AL645608.6 chr1 904834 915976 + AL662884.1 chr6 32184733 32185882 - AP001107.5 chr11 66409158 66417137 + BACH1-IT2 chr21 29370497 29373709 + EPB41L4A-AS1 chr5 112160526 112164818 + MIRLET7BHG chr22 46053869 46113928 + NOP14-AS1 chr4 2934882 2961738 + NORAD chr20 36045618 36051018 - SNHG3 chr1 28505980 28510892 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.