exRNAdisease

Entry Detail

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General Information

Database ID: exR0429027 RNA Name: AHCYL2 RNA Type: mRNA Chromosome: chr7 Starnd: + Coordinate: Start Site(bp): 129225023 End Site(bp): 129430211 External Links: ENSG00000158467

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AHCYL1 chr1 109984765 110023742 + IQCC chr1 32205661 32208687 + HSP90AB1 chr6 44246166 44253888 + HMGCS1 chr5 43287470 43313512 - MFAP3L chr4 169986597 170033031 - RPL22L1 chr3 170864875 170870208 - LIN28A chr1 26410817 26429728 + CD9 chr12 6199715 6238271 + TPT1 chr13 45333471 45341370 - NFYB chr12 104117086 104138241 - LMNB2 chr19 2427638 2456959 - ARPP19 chr15 52547045 52569883 - CFL1 chr11 65823022 65862026 - RNPS1 chr16 2253116 2268397 - RCAN1 chr21 34513142 34615113 - DNAAF5 chr7 726699 786475 + PGK1 chrX 77910739 78129295 + GGA2 chr16 23463542 23521995 - HERC2 chr15 28111040 28322172 - SYT11 chr1 155859567 155885199 + KMT5B chr11 68154863 68213828 - CSTF2 chrX 100820359 100840932 + MRPL15 chr8 54135241 54148514 + EEF1D chr8 143579697 143599541 - AKIRIN1 chr1 38991276 39006059 + RPS14 chr5 150442635 150449739 - CDK2AP1 chr12 123250112 123272334 - TMUB1 chr7 151081085 151083493 - TUBA1B chr12 49127782 49131397 - UTP3 chr4 70688532 70690551 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009022.1 chr16 69976297 70065948 - AL049796.1 chr1 93847174 93848939 + LINC01535 chr19 37251885 37265535 + U91319.1 chr16 13246232 13563388 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.