exRNAdisease

Entry Detail

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General Information

Database ID: exR0429039 RNA Name: AIF1L RNA Type: mRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 131096476 End Site(bp): 131123152 External Links: ENSG00000126878

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand APEX1 chr14 20455191 20457772 + HSPD1 chr2 197486584 197516737 - SNRPG chr2 70281362 70293740 - SHC1 chr1 154962298 154974395 - AC008763.2 chr19 7629796 7643048 + PIM2 chrX 48913182 48919024 - HSP90AB1 chr6 44246166 44253888 + MT-ND2 chrMT 4470 5511 + ALDH16A1 chr19 49453225 49471050 + HK1 chr10 69269984 69401884 + RPL11 chr1 23691742 23696835 + PDS5B chr13 32586452 32778019 + MIF chr22 23894383 23895227 + XRCC5 chr2 216107464 216206303 + C17orf113 chr17 42038232 42050601 - TUBA1C chr12 49188736 49274603 + LRRC75A chr17 16441577 16492193 - OTUD1 chr10 23439458 23442390 + INTS3 chr1 153728050 153774808 + ZNF449 chrX 135344796 135363413 + FTH1 chr11 61959718 61967634 - SRPRB chr3 133784023 133825772 + MARCKSL1 chr1 32333839 32336233 - MCM3AP chr21 46235133 46286297 - PCDHGB5 chr5 141397987 141512979 + ERH chr14 69380128 69398299 - PPCDC chr15 75023586 75117462 + SMARCD1 chr12 50085200 50100707 + RPL18 chr19 48615328 48619184 - RBM14 chr11 66616582 66627347 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-641 chr19 40282603 40282626 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008267.5 chr7 66493607 66495758 + AC069503.1 chr12 122007434 122020063 - AL021707.3 chr22 38734730 38738990 + MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.