exRNAdisease

Entry Detail

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General Information

Database ID: exR0429054 RNA Name: AK2 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 33007940 End Site(bp): 33080996 External Links: ENSG00000004455

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand IFI30 chr19 18173162 18178117 + C19orf53 chr19 13774456 13778773 + RBM10 chrX 47145221 47186813 + RPL5 chr1 92832013 92841924 + SAP30BP chr17 75667251 75708062 + PPP2CA chr5 134194332 134226073 - RPLP1 chr15 69452814 69456205 + REXO1 chr19 1815248 1848483 - ARL2BP chr16 57245259 57253635 + GTF3C5 chr9 133030675 133058503 + GRID1 chr10 85599552 86366795 - OGFOD3 chr17 82389210 82418637 - MRPL4 chr19 10251901 10260055 + EIF4E chr4 98871684 98930637 - DDIT4 chr10 72273924 72276036 + MYBBP1A chr17 4538897 4555631 - MZT1 chr13 72708367 72727629 - AC011448.1 chr19 19516227 19536076 + MTRNR2L1 chr17 22523111 22524663 + CDC42SE1 chr1 151050971 151070325 - HAUS1 chr18 46104378 46128333 + POMP chr13 28659104 28678959 + AP2A1 chr19 49766968 49807113 + HLA-B chr6 31269491 31357188 - OCIAD1 chr4 48805212 48861817 + MAL2 chr8 119165034 119245673 + RPS5 chr19 58386400 58394806 + HLA-DQB1 chr6 32659467 32668383 - STRAP chr12 15882387 15903478 + SLC25A37 chr8 23528956 23575463 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-204-5p chr9 70810031 70810052 - hsa-miR-211-5p chr15 31065095 31065116 - hsa-miR-141-3p chr12 6964155 6964176 + hsa-miR-299-3p chr14 101023832 101023853 + hsa-miR-1224-5p chr3 184241405 184241423 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AL121985.1 chr1 160670778 160699761 + GUSBP11 chr22 23638487 23717356 - LINC02381 chr12 54126082 54147485 + LINC02539 chr6 137730170 137792835 - MALAT1 chr11 65497688 65506516 + SNHG17 chr20 38419638 38435409 - SNHG5 chr6 85650491 85678932 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.