exRNAdisease

Entry Detail

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General Information

Database ID: exR0429056 RNA Name: AK4 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 65147549 End Site(bp): 65232145 External Links: ENSG00000162433

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MYH9 chr22 36281277 36388067 - MAPKAPK2 chr1 206684944 206734283 + RER1 chr1 2391775 2405442 + RELA chr11 65653597 65663090 - SFXN1 chr5 175477062 175529742 + SMN2 chr5 70049612 70078522 + TNIP1 chr5 151029945 151093577 - TM9SF3 chr10 96518110 96587452 - DPH2 chr1 43970000 43973369 + STAT1 chr2 190908460 191020960 - CD22 chr19 35319261 35347361 + IGF2 chr11 2129112 2141238 - MTRNR2L1 chr17 22523111 22524663 + UBE3A chr15 25333728 25439051 - NFATC2IP chr16 28950807 28967097 + RPL14 chr3 40457292 40468587 + SDCBP chr8 58552924 58582859 + DHX15 chr4 24517441 24584554 - TFRC chr3 196027183 196082096 - PPP5D1 chr19 46480796 46601200 - YWHAB chr20 44885702 44908532 + ACTG1 chr17 81509971 81523847 - RBCK1 chr20 407498 430966 + TMED5 chr1 93149742 93180516 - CBX3 chr7 26201162 26213607 + APOE chr19 44905791 44909393 + RPL15 chr3 23916545 23924374 + HLA-B chr6 31269491 31357188 - PATZ1 chr22 31325804 31346346 - CD47 chr3 108043091 108091862 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-362-3p chrX 50009005 50009026 + hsa-miR-556-3p chr1 162342600 162342621 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL359924.1 chr1 237862175 237928321 + AL627309.5 chr1 141474 173862 - BX284668.2 chr1 16870945 16883659 + LINC01641 chr1 227393554 227431035 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.