exRNAdisease

Entry Detail

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General Information

Database ID: exR0429061 RNA Name: AKAP1 RNA Type: mRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 57085092 End Site(bp): 57121346 External Links: ENSG00000121057

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand LRCH3 chr3 197791226 197888436 + TP53I11 chr11 44885903 44951306 - UNKL chr16 1363205 1414751 - NUP210 chr3 13316235 13420322 - CUEDC2 chr10 102423245 102432584 - TAF6 chr7 100107070 100119841 - MT-ND4 chrMT 10760 12137 + YME1L1 chr10 27110112 27155266 - NOP56 chr20 2652593 2658393 + TAOK2 chr16 29973868 29992261 + LIN28A chr1 26410817 26429728 + TBC1D9B chr5 179862066 179907859 - PLCG2 chr16 81739097 81962685 + CYBRD1 chr2 171522247 171558129 + ABCE1 chr4 145098288 145129524 + NAP1L4 chr11 2944431 2992377 - CC2D1B chr1 52345723 52366193 - WASF2 chr1 27404230 27490167 - TMEM41A chr3 185476496 185499057 - NAPA chr19 47487637 47515091 - TPRG1L chr1 3625015 3630127 + TOP2A chr17 40388525 40417896 - RAN chr12 130872037 130877678 + SENP3-EIF4A1 chr17 7563287 7578715 + TSC22D1 chr13 44432143 44577147 - SLC2A11 chr22 23856703 23886309 + FKRP chr19 46746046 46776988 + UBL5 chr19 9827892 9830115 + LMAN2 chr5 177331567 177351668 - POLL chr10 101578882 101588270 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-1197 chr14 101025620 101025640 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005618.1 chr5 141326210 141329357 + AC016876.2 chr17 7581964 7584086 - AC008738.1 chr19 33178056 33178651 + ERVK13-1 chr16 2660348 2682379 - LINC00458 chr13 54115783 54142319 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.