exRNAdisease

Entry Detail

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General Information

Database ID: exR0429063 RNA Name: AKAP11 RNA Type: mRNA Chromosome: chr13 Starnd: + Coordinate: Start Site(bp): 42272152 End Site(bp): 42323261 External Links: ENSG00000023516

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005670.2 chr17 46923133 47049932 + MAPK1 chr22 21754500 21867680 - ZNF100 chr19 21722771 21767579 - CANX chr5 179678628 179731641 + TPI1 chr12 6867119 6870948 + AIFM1 chrX 130129362 130165887 - RAB3GAP2 chr1 220148293 220272453 - TOP3A chr17 18271428 18315007 - NOC2L chr1 944203 959309 - DYRK1A chr21 37365573 37526358 + PSMB1 chr6 170535120 170553307 - CSNK1A1 chr5 149492982 149551471 - ZNF711 chrX 85244032 85273362 + RPL15 chr3 23916545 23924374 + C16orf91 chr16 1419752 1420756 - ATP13A2 chr1 16985958 17011928 - NPTX2 chr7 98617285 98629869 + EDARADD chr1 236348257 236502915 + MAZ chr16 29806106 29811164 + SEC31A chr4 82818509 82901166 - HOMEZ chr14 23272422 23299447 - PIK3CB chr3 138652698 138834928 - HLA-DRB1 chr6 32578769 32589848 - CCT8 chr21 29055805 29073797 - FSCN1 chr7 5592816 5606655 + RPL22 chr1 6185020 6209389 - CXXC5 chr5 139647299 139683882 + LDHA chr11 18394560 18408425 + CMPK1 chr1 47333797 47378839 + KCMF1 chr2 84971093 85059472 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-130a-3p chr11 57641252 57641273 + hsa-miR-362-3p chrX 50009005 50009026 + hsa-miR-541-3p chr14 101064548 101064569 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand MEG3 chr14 100779410 100861031 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.