exRNAdisease

Entry Detail

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General Information

Database ID: exR0429071 RNA Name: AKAP8 RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 15353385 End Site(bp): 15379798 External Links: ENSG00000105127

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANAPC7 chr12 110372900 110403730 - SHQ1 chr3 72749277 72861914 - ZNF500 chr16 4748239 4767624 - UBN1 chr16 4846665 4882401 + CALR chr19 12938578 12944489 + ICE2 chr15 60419609 60479160 - L1TD1 chr1 62194849 62212328 + TRIP12 chr2 229763838 229923239 - ZNF43 chr19 21804949 21852125 - GMPS chr3 155870650 155944020 + ABCC1 chr16 15949577 16143074 + RPL36A-HNRNPH2 chrX 101391011 101412297 + BAMBI chr10 28677510 28682932 + NACA2 chr17 61590421 61591219 - ZZEF1 chr17 4004445 4143030 - PPP1R12C chr19 55090914 55117637 - TLE3 chr15 70047790 70098176 - NCL chr2 231453531 231483641 - DCAF10 chr9 37800554 37867666 + MIXL1 chr1 226223618 226227054 + NAT10 chr11 34105617 34147670 + ALDOA chr16 30064164 30070457 + MON1B chr16 77190835 77202398 + TIMMDC1 chr3 119498547 119525090 + SH3PXD2A chr10 103594027 103855543 - ATF6B chr6 32115264 32128253 - CDK7 chr5 69234795 69277430 + RIPOR1 chr16 67518418 67546788 + NPC2 chr14 74476192 74494177 - CACNG6 chr19 53992288 54012669 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL355075.4 chr14 20343048 20343685 - LINC01248 chr2 5602505 5691488 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.