exRNAdisease

Entry Detail

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General Information

Database ID: exR0429072 RNA Name: AKAP8L RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 15380050 End Site(bp): 15419141 External Links: ENSG00000011243

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AL357673.1 chr1 54132686 54200073 - KRT8 chr12 52897187 52949954 - C6orf136 chr6 30647039 30653210 + NCKAP1L chr12 54497752 54548243 + OS9 chr12 57693955 57721557 + STX12 chr1 27773219 27824443 + MBD3 chr19 1573596 1592865 - RPN1 chr3 128619969 128681075 - PTP4A1 chr6 63521746 63583436 + ACTN4 chr19 38647649 38731589 + CENPH chr5 69189574 69210357 + RPL13 chr16 89560657 89566828 + PTMA chr2 231706895 231713541 + MLST8 chr16 2204248 2209453 + FNTA chr8 43034194 43085788 + MCM2 chr3 127598410 127622436 + GRB2 chr17 75318076 75405709 - CPSF1 chr8 144393229 144409335 - DBN1 chr5 177456608 177474401 - EIF3A chr10 119033670 119080823 - RPL13A chr19 49487554 49492308 + GALNT2 chr1 230057990 230282122 + TPT1 chr13 45333471 45341370 - NOMO1 chr16 14833721 14896157 + NAA30 chr14 57390544 57415906 + NDUFB8 chr10 100523740 100530000 - RPL37A chr2 216498825 216579180 + STK25 chr2 241492670 241509730 - LIN28A chr1 26410817 26429728 + APBA3 chr19 3750772 3761692 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL021368.4 chr6 57919912 57961382 - MALAT1 chr11 65497688 65506516 + RMRP chr9 35657751 35658018 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.