exRNAdisease

Entry Detail

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General Information

Database ID: exR0429074 RNA Name: AKIP1 RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 8911139 End Site(bp): 8920084 External Links: ENSG00000166452

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CBX3 chr7 26201162 26213607 + FSCN1 chr7 5592816 5606655 + MDM2 chr12 68808177 68850686 + OAS3 chr12 112938444 112973251 + COPS7B chr2 231781671 231809254 + EIF1 chr17 41688885 41692668 + MRPL49 chr11 65122183 65127371 + SLC2A1 chr1 42925375 42958868 - B2M chr15 44711487 44718877 + NIPSNAP1 chr22 29554808 29581327 - AK4 chr1 65147549 65232145 + SLC25A6 chrX 1386152 1392113 - DHX15 chr4 24517441 24584554 - VLDLR chr9 2621787 2660056 + AL136454.1 chr1 192716132 192716653 + TXNL1 chr18 56597209 56651600 - CHKB-CPT1B chr22 50568869 50582965 - KRT7 chr12 52232520 52252186 + TAGLN2 chr1 159918107 159925732 - CHMP1A chr16 89644435 89657721 - FP565260.6 chr21 5155499 5165472 - FP565260.2 chr21 5116343 5133805 - OST4 chr2 27070472 27071654 - TSTD2 chr9 97600080 97633368 - PSMA5 chr1 109399042 109426448 - PPP2R1A chr19 52190048 52229518 + IL21R chr16 27402174 27452042 + THOC5 chr22 29505879 29555216 - GPSM3 chr6 32190766 32195523 - MAT2A chr2 85539168 85545281 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-4426 chr1 192716333 192716349 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand DANCR chr4 52712404 52720351 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.