exRNAdisease

Entry Detail

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General Information

Database ID: exR0429076 RNA Name: AKIRIN2 RNA Type: mRNA Chromosome: chr6 Starnd: - Coordinate: Start Site(bp): 87674860 End Site(bp): 87702233 External Links: ENSG00000135334

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RPS27 chr1 153990762 153992155 + PLCB3 chr11 64251523 64269150 + TM9SF4 chr20 32109714 32167258 + SLAIN2 chr4 48341529 48426201 + COX4I1 chr16 85798633 85807068 + FASN chr17 82078338 82098294 - ADGRL3 chr4 61201258 62078335 + PITX1 chr5 135027734 135034813 - RPLP0 chr12 120196699 120201235 - KLC2 chr11 66257294 66267860 + SOX4 chr6 21593751 21598619 + UBE2Z chr17 48908407 48929056 + SMARCAL1 chr2 216412414 216483053 + HCN1 chr5 45254948 45696498 - HLA-DRA chr6 32439878 32445046 + SECISBP2 chr9 89318500 89359663 + TAF7 chr5 141260225 141320784 - ELOVL5 chr6 53267398 53349179 - RPL18 chr19 48615328 48619184 - UBC chr12 124911604 124917368 - SCAND1 chr20 35953617 35959472 - TUBA1C chr12 49188736 49274603 + RACGAP1 chr12 49976923 50033136 - ACTR10 chr14 58200080 58235636 + HSP90AB1 chr6 44246166 44253888 + AFTPH chr2 64524305 64593005 + EDARADD chr1 236348257 236502915 + UBE2Q2L chr15 84172490 84182234 + MFSD11 chr17 76735865 76781449 + TP53 chr17 7661779 7687550 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-3648 chr21 8987026 8987046 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC079949.1 chr12 127142029 127146532 - AL139819.1 chr10 100335563 100346390 - RASAL2-AS1 chr1 178090677 178093984 - SNHG25 chr17 64145970 64146476 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.