exRNAdisease

Entry Detail

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General Information

Database ID: exR0429086 RNA Name: AKR7A2 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 19303965 End Site(bp): 19312146 External Links: ENSG00000053371

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HSD17B12 chr11 43680680 43856617 + PRELID1 chr5 177303799 177306949 + SAMD11 chr1 923928 944581 + FEM1A chr19 4791734 4801273 + AC073508.2 chr17 40627356 40665141 - MCAM chr11 119308529 119321521 - HSPA1B chr6 31827738 31830254 + SHB chr9 37915898 38069227 - VIM chr10 17228241 17237593 + GDPD3 chr16 30104810 30113537 - ELFN2 chr22 37367960 37427479 - DDX3Y chrY 12904108 12920478 + CD74 chr5 150400041 150412929 - HNRNPA2B1 chr7 26173057 26201529 - ATP1A1 chr1 116372668 116410261 + MIF chr22 23894383 23895227 + NPTX1 chr17 80466834 80477843 - SMARCE1 chr17 40624962 40648654 - DDB1 chr11 61299451 61342596 - TRIO chr5 14143342 14532128 + RPLP1 chr15 69452814 69456205 + CHMP2A chr19 58551566 58555105 - HMGA1 chr6 34236873 34246231 + CAD chr2 27217369 27243943 + ID1 chr20 31605283 31606515 + NR1D2 chr3 23945286 23980617 + RPL10 chrX 154389955 154409168 + RASSF3 chr12 64507001 64697564 + MESD chr15 80946289 80989828 - RPS8 chr1 44775251 44778779 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AP000317.2 chr21 34073592 34360033 + MALAT1 chr11 65497688 65506516 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.