exRNAdisease

Entry Detail

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General Information

Database ID: exR0429087 RNA Name: AKT1 RNA Type: mRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 104769349 End Site(bp): 104795751 External Links: ENSG00000142208

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PPM1B chr2 44167969 44244384 + KEAP1 chr19 10486125 10503558 - AC010422.3 chr19 12643831 12648397 - FKBP1A chr20 1368978 1393172 - ACACA chr17 37084992 37406836 - TUFM chr16 28842411 28846348 - SCFD2 chr4 52872982 53366066 - P4HB chr17 81843161 81860624 - CRELD1 chr3 9933816 9945406 + SIGIRR chr11 405716 417455 - KDM4B chr19 4969113 5153598 + TMEM106C chr12 47963569 47968878 + FAT1 chr4 186587794 186726722 - POU5F1 chr6 31164337 31180731 - INTS5 chr11 62646848 62653302 - ZC3H14 chr14 88562970 88627596 + TPI1 chr12 6867119 6870948 + CA14 chr1 150257251 150265078 + KDELR3 chr22 38468078 38483447 + DLG3 chrX 70444835 70505490 + FBRSL1 chr12 132489551 132585188 + MOV10 chr1 112673141 112700746 + ENAH chr1 225486835 225653142 - EEF1A1 chr6 73515750 73523797 - RARRES2 chr7 150338317 150341662 - MVD chr16 88651935 88663161 - TUBB chr6 30720352 30725426 + HNRNPL chr19 38836388 38852347 - HPCAL1 chr2 10302889 10427617 + PPA1 chr10 70202835 70233911 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004816.1 chr14 70809841 70815994 + AC012313.3 chr19 58346854 58362751 - AC067930.1 chr8 143579636 143580670 + GSEC chr11 126340889 126355587 - MIR663AHG chr20 26167817 26251546 - PDCD4-AS1 chr10 110869868 110872233 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.