exRNAdisease

Entry Detail

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General Information

Database ID: exR0429090 RNA Name: AKT3 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 243488233 End Site(bp): 243851079 External Links: ENSG00000117020

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NUP107 chr12 68686951 68745809 + FUCA1 chr1 23845077 23868294 - HNRNPK chr9 83968083 83980616 - RPL37 chr5 40825262 40835222 - EDEM2 chr20 35115364 35147336 - PRDX6 chr1 173477330 173488815 + HLA-C chr6 31268749 31272130 - MAP3K7 chr6 90513573 90587072 - SRSF4 chr1 29147743 29181900 - IPMK chr10 58191517 58267894 - POLR2F chr22 37952607 38041915 + IST1 chr16 71845996 71931199 + ID1 chr20 31605283 31606515 + L1TD1 chr1 62194849 62212328 + SF3B1 chr2 197388515 197435091 - SDCCAG8 chr1 243256034 243500091 + POLR1D chr13 27620742 27744237 + ESRP1 chr8 94641074 94707466 + LAPTM4B chr8 97775057 97853013 + AKT2 chr19 40230317 40285536 - STK4 chr20 44966479 45080021 + HNRNPL chr19 38836388 38852347 - PAPOLA chr14 96501433 96567111 + PKN1 chr19 14433053 14471867 + IL6R chr1 154405193 154469450 + TIMM10B chr11 6481501 6484681 + RPL13A chr19 49487554 49492308 + RTN4R chr22 20241415 20283246 - ANKFY1 chr17 4163821 4263995 - SGSH chr17 80206716 80220923 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand RMRP chr9 35657751 35658018 - SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.