exRNAdisease

Entry Detail

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General Information

Database ID: exR0429099 RNA Name: AL136454.1 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 192716132 End Site(bp): 192716653 External Links: ENSG00000231767

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RNF181 chr2 85595725 85597708 + RILPL1 chr12 123470054 123533719 - TKFC chr11 61333210 61353295 + DBN1 chr5 177456608 177474401 - EDARADD chr1 236348257 236502915 + TOM1 chr22 35299275 35347992 + ACTA1 chr1 229431245 229434098 - NLGN4Y chrY 14522573 14845650 + RABL2B chr22 50767501 50783663 - MT-CO3 chrMT 9207 9990 + OTUD4 chr4 145110838 145180589 - DAB1 chr1 56994778 58546734 - POLD4 chr11 67350772 67356972 - TMEM50A chr1 25338317 25362361 + USP10 chr16 84699978 84779922 + TARDBP chr1 11012344 11026420 + UROD chr1 45010950 45015575 + UBC chr12 124911604 124917368 - HECTD1 chr14 31100112 31207804 - TUBB chr6 30720352 30725426 + RPS28 chr19 8321158 8323340 + TUBA1C chr12 49188736 49274603 + TRIP6 chr7 100867387 100873454 + SRSF10 chr1 23964347 23980927 - CD52 chr1 26317958 26320523 + BTK chrX 101349447 101390796 - ADAR chr1 154582057 154628013 - RBM8A chr1 145917714 145927678 - AKIP1 chr11 8911139 8920084 + TMEM170A chr16 75443054 75465497 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-4426 chr1 192716333 192716349 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008105.3 chr17 45190931 45222222 - AC012236.1 chr15 31221999 31230838 - AC016876.2 chr17 7581964 7584086 - AC023509.1 chr12 53441741 53467528 + AC068792.1 chr12 31443792 31444208 - AC090152.1 chr8 59119040 59123478 + AC105942.1 chr1 94927361 94963616 + AC144548.1 chr12 110387463 110445548 - AC245014.3 chr1 145281116 145281462 + AC138761.1 chr17 22266395 22288301 + AL031005.1 chr1 21266082 21267251 + AL355472.2 chr1 234357006 234365828 + AL365258.2 chr1 197757319 197761965 + HCP5 chr6 31463170 31478936 + LINC00337 chr1 6234692 6239444 + LINC00543 chr13 27953526 27955370 + LINC01641 chr1 227393554 227431035 + SCAMP1-AS1 chr5 78342365 78360507 - SNHG1 chr11 62851984 62855953 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.