exRNAdisease

Entry Detail

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General Information

Database ID: exR0429106 RNA Name: AL365205.1 RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 41780349 End Site(bp): 41790141 External Links: ENSG00000124593

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand OGFR chr20 62804835 62814000 + RASGRF2 chr5 80960363 81230162 + HNRNPA2B1 chr7 26173057 26201529 - NCKAP5L chr12 49791146 49828750 - NIN chr14 50719763 50831121 - E2F4 chr16 67192155 67198918 + C2orf81 chr2 74414176 74421591 - TOMM6 chr6 41787662 41789898 + RINT1 chr7 105532169 105567677 + STX16-NPEPL1 chr20 58651434 58715410 + U2SURP chr3 142964497 143060725 + NPEPPS chr17 47522942 47623276 + HTT chr4 3041422 3243960 + CALM1 chr14 90396502 90408268 + ALDOA chr16 30064164 30070457 + GDAP1 chr8 74321130 74488872 + CPS1 chr2 210477682 210679107 + TSC2 chr16 2047967 2089491 + RCN2 chr15 76931738 76954393 + FUS chr16 31180110 31194871 + EI24 chr11 125569280 125584684 + ATG14 chr14 55366391 55411830 - ATP2C1 chr3 130850595 131016712 + PRDX6 chr1 173477330 173488815 + DAB2 chr5 39371675 39462300 - PDIA3 chr15 43746410 43773278 + TCF12 chr15 56918623 57299281 + POLR1D chr13 27620742 27744237 + PPP1R12C chr19 55090914 55117637 - PRKAR1A chr17 68511780 68551319 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-512-3p chr19 53666729 53666750 + hsa-miR-671-5p chr7 151238449 151238471 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL357078.2 chr1 65003470 65004087 - HLA-F-AS1 chr6 29726601 29749049 - ITGB2-AS1 chr21 44921051 44929678 + LINC00847 chr5 180830326 180839742 + NEAT1 chr11 65422774 65445540 + SNHG1 chr11 62851984 62855953 - UBA6-AS1 chr4 67701209 68080952 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.