exRNAdisease

Entry Detail

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General Information

Database ID: exR0429125 RNA Name: ALDH4A1 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 18871430 End Site(bp): 18902724 External Links: ENSG00000159423

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DDI2 chr1 15617458 15669044 + LIN28A chr1 26410817 26429728 + EIF5 chr14 103333544 103345025 + RPL7A chr9 133348218 133351426 + SLC39A1 chr1 153959099 153968184 - GRB2 chr17 75318076 75405709 - RPL23 chr17 38847860 38853764 - ERBB2 chr17 39687914 39730426 + CASP7 chr10 113679162 113730907 + METTL16 chr17 2405562 2511891 - SERF2 chr15 43777087 43802589 + ESPL1 chr12 53268299 53293638 + SBF1 chr22 50445000 50475035 - ACTB chr7 5527148 5563784 - OSBPL9 chr1 51577179 51798427 + HLA-DRB1 chr6 32578769 32589848 - EXOSC7 chr3 44975241 45036066 + DCTN1 chr2 74361154 74392087 - HDHD5 chr22 17137511 17165287 - RHNO1 chr12 2876258 2889524 + ZDHHC16 chr10 97446170 97457370 + EIF3H chr8 116642130 116766925 - BCAM chr19 44809071 44821421 + FRAS1 chr4 78057323 78544269 + NKTR chr3 42600655 42648735 + TUBA1A chr12 49184795 49189080 - EEF1B2 chr2 206159585 206162928 + SIGIRR chr11 405716 417455 - FUS chr16 31180110 31194871 + CTNNBIP1 chr1 9848276 9910336 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + LINC01641 chr1 227393554 227431035 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.