exRNAdisease

Entry Detail

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General Information

Database ID: exR0429126 RNA Name: ALDH5A1 RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 24494867 End Site(bp): 24537207 External Links: ENSG00000112294

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand YWHAB chr20 44885702 44908532 + B2M chr15 44711487 44718877 + SLC25A6 chrX 1386152 1392113 - MAP7D1 chr1 36155579 36180849 + TTC19 chr17 15999784 16045015 + EIF3E chr8 108201216 108435333 - FBRSL1 chr12 132489551 132585188 + IRF2BP2 chr1 234604269 234609525 - USP53 chr4 119212587 119295517 + SH3GLB2 chr9 129007036 129028303 - MYO10 chr5 16661907 16936288 - TET3 chr2 73986404 74108176 + STK11IP chr2 219597857 219616451 + NFKB2 chr10 102394110 102402524 + MAPK12 chr22 50245450 50261716 - ERRFI1 chr1 8004404 8026309 - PNMA2 chr8 26504701 26514092 - HUWE1 chrX 53532096 53686728 - GTF2F1 chr19 6379572 6393981 - RPS6 chr9 19375715 19380236 - RPL37A chr2 216498825 216579180 + SLX1A chr16 30193887 30197561 + BAX chr19 48954815 48961798 + IGF2 chr11 2129112 2141238 - KLC4 chr6 43040777 43075095 + ZNF33A chr10 38010650 38065088 + ZNF12 chr7 6688433 6706947 - LASP1 chr17 38869859 38921770 + RPL13 chr16 89560657 89566828 + FAM104B chrX 55143102 55161310 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-129-5p chr7 128207876 128207896 + hsa-miR-330-5p chr19 45639049 45639070 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022201.2 chr2 70301451 70302072 + AL645941.1 chr6 32970232 32970886 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.