exRNAdisease

Entry Detail

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General Information

Database ID: exR0429415 RNA Name: APP RNA Type: mRNA Chromosome: chr21 Starnd: - Coordinate: Start Site(bp): 25880550 End Site(bp): 26171128 External Links: ENSG00000142192

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCF2 chr7 151207837 151227166 - ABRACL chr6 139028745 139043302 + AC008695.1 chr5 131425891 131796983 - AC012254.2 chr18 47108188 47176345 - AC093525.2 chr16 2496032 2520218 + AC138811.2 chr16 18788063 18801519 - AC245033.1 chr15 82536788 82573194 - ACAA2 chr18 49782164 49813953 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACTR10 chr14 58200080 58235636 + ADAR chr1 154582057 154628013 - ADI1 chr2 3497366 3519531 - ADK chr10 74151202 74709963 + AGL chr1 99850361 99924023 + AGPAT1 chr6 32168212 32178096 - AHNAK chr11 62433542 62556235 - AIF1L chr9 131096476 131123152 + AKIRIN1 chr1 38991276 39006059 + AL133352.1 chr10 100505628 100529881 - AL136454.1 chr1 192716132 192716653 + AL139011.2 chr1 160216800 160285130 - AL355916.3 chr14 61529128 61657964 + AL589666.1 chr6 85557978 85615234 - ALAS1 chr3 52198086 52214327 + ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-17-5p chr13 91350618 91350640 + hsa-miR-20a-5p chr13 91351072 91351094 + hsa-miR-21-5p chr17 59841273 59841294 + hsa-miR-29a-3p chr7 130876748 130876769 - hsa-miR-29b-3p chr7 130877467 130877489 - hsa-miR-106a-5p chrX 134170244 134170266 - hsa-miR-214-3p chr1 172138816 172138837 - hsa-miR-106b-5p chr7 100094043 100094063 - hsa-miR-29c-3p chr1 207801865 207801886 - hsa-miR-302a-3p chr4 112648186 112648208 - hsa-miR-302c-3p chr4 112648366 112648388 - hsa-miR-373-3p chr19 53788748 53788770 + hsa-miR-20b-5p chrX 134169850 134169872 - hsa-miR-520e-3p chr19 53675764 53675784 + hsa-miR-520a-3p chr19 53690933 53690954 + hsa-miR-520b-3p chr19 53701267 53701287 + hsa-miR-520c-3p chr19 53707506 53707527 + hsa-miR-520d-3p chr19 53720149 53720170 + hsa-miR-4426 chr1 192716333 192716349 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC021078.1 chr5 149494314 149504670 - AC023509.1 chr12 53441741 53467528 + AC024940.6 chr12 31280422 31280895 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.