exRNAdisease

Entry Detail

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General Information

Database ID: exR0432548 RNA Name: DYNC1H1 RNA Type: mRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101964573 End Site(bp): 102056443 External Links: ENSG00000197102

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AATF chr17 36948954 37056871 + AC090004.1 chr3 14135217 14148252 + AC093525.1 chr16 2513965 2527955 + AC093525.2 chr16 2496032 2520218 + AC104109.3 chr5 134167170 134226071 - AC138969.1 chr16 16317444 16350590 + AC245033.1 chr15 82536788 82573194 - ACAA2 chr18 49782164 49813953 - ADAMTS15 chr11 130448974 130476641 + ADCY3 chr2 24819169 24919839 - ADD2 chr2 70607618 70768225 - AGRN chr1 1020120 1056118 + AIF1L chr9 131096476 131123152 + AK3 chr9 4709556 4742043 - AKAP1 chr17 57085092 57121346 + AL139300.1 chr14 103562962 103685924 + AL162417.1 chr9 133098121 133163914 - ALDH18A1 chr10 95605941 95656711 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-21-5p chr17 59841273 59841294 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005899.4 chr17 32328441 32329395 + AC008124.1 chr12 45718046 45727775 - AC110285.2 chr17 81388126 81390319 - AC245014.3 chr1 145281116 145281462 + AL022157.1 chrX 57121662 57127243 + AL110115.2 chr20 31580890 31581214 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.