exRNAdisease

Entry Detail

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General Information

Database ID: exR0432733 RNA Name: EIF4A2 RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 186783205 End Site(bp): 186789897 External Links: ENSG00000156976

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABT1 chr6 26596953 26600739 + AC005832.4 chr12 4604944 4662643 + AC008878.3 chr19 7382834 7470241 + AC008982.1 chr19 38817471 38840178 - AC036214.3 chr8 79918860 80080775 - AC073508.2 chr17 40627356 40665141 - AC245033.1 chr15 82536788 82573194 - ACAD9 chr3 128879596 128916067 + ACTG1 chr17 81509971 81523847 - ADAM10 chr15 58588809 58749791 - ADD3 chr10 109996368 110135565 + ADK chr10 74151202 74709963 + ADRM1 chr20 62302093 62308862 + AEN chr15 88621337 88632281 + AFTPH chr2 64524305 64593005 + AGPAT3 chr21 43865223 43987592 + AHCY chr20 34280268 34311802 - ALDH6A1 chr14 74056847 74084492 - ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-19b-3p chr13 91351245 91351267 + hsa-miR-21-5p chr17 59841273 59841294 + hsa-miR-1248 chr3 186786675 186786701 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC016876.2 chr17 7581964 7584086 - AC051619.7 chr15 45200325 45200632 - AC105942.1 chr1 94927361 94963616 + AC106864.1 chr4 112693047 112706810 - AC144548.1 chr12 110387463 110445548 - AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.