exRNAdisease

Entry Detail

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General Information

Database ID: exR0434625 RNA Name: HMGCS1 RNA Type: mRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 43287470 End Site(bp): 43313512 External Links: ENSG00000112972

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAAS chr12 53307456 53324864 - AC008575.1 chr5 112827213 112867582 + AC010646.1 chr19 17235940 17255448 - AC092143.1 chr16 89919165 89936092 + AC120057.2 chr17 7240427 7244635 - ACOT9 chrX 23701055 23766475 - ADAR chr1 154582057 154628013 - ADNP chr20 50888916 50931437 - AEBP1 chr7 44104345 44114562 + AGFG1 chr2 227472152 227561214 + AHCYL2 chr7 129225023 129430211 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-let-7d-5p chr9 94178841 94178862 + hsa-miR-18a-5p chr13 91350756 91350778 + hsa-miR-199a-5p chr1 172144592 172144614 - hsa-miR-34a-5p chr1 9151735 9151756 - hsa-miR-199b-5p chr9 128244783 128244805 - hsa-miR-23b-3p chr9 95085265 95085287 + hsa-miR-302b-3p chr4 112648489 112648511 - hsa-miR-296-3p chr20 58817626 58817647 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004847.1 chr7 44958999 44960909 - AC016876.2 chr17 7581964 7584086 - AC079781.5 chr7 97851688 97972985 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.