exRNAdisease

Entry Detail

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General Information

Database ID: exR0441589 RNA Name: SRSF1 RNA Type: mRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 58000919 End Site(bp): 58007346 External Links: ENSG00000136450

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AASS chr7 122073549 122144255 - ABCA7 chr19 1039997 1065572 + ABHD14A-ACY1 chr3 51974706 51989183 + AC010422.3 chr19 12643831 12648397 - AC013394.1 chr15 92883413 92949230 + AC015813.2 chr17 57989038 58007246 - AC027796.3 chr17 3585149 3636249 - AC073082.1 chr2 48632291 48755724 - AC120057.2 chr17 7240427 7244635 - AC245033.1 chr15 82536788 82573194 - ACBD6 chr1 180269653 180502954 - ACPP chr3 132317369 132368298 + ACTB chr7 5527148 5563784 - ACTL6A chr3 179562886 179588407 + ACTR3 chr2 113890063 113962596 + ACY1 chr3 51983340 51989197 + ADPGK chr15 72751369 72785846 - AEN chr15 88621337 88632281 + AGPAT5 chr8 6708642 6761503 + AHCY chr20 34280268 34311802 - AHSA1 chr14 77457870 77469472 + AKT2 chr19 40230317 40285536 - ALDH6A1 chr14 74056847 74084492 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-18a-5p chr13 91350756 91350778 + hsa-miR-7705 chr8 100703002 100703024 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC015813.1 chr17 57989039 57994850 - AC025575.2 chr12 71047402 71118247 - AC132217.1 chr11 2129121 2129964 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.