exRNAdisease

Entry Detail

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General Information

Database ID: exR0442703 RNA Name: TNPO2 RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 12699194 End Site(bp): 12724011 External Links: ENSG00000105576

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAMP chr2 218264123 218270257 - ABCE1 chr4 145098288 145129524 + ABL2 chr1 179099330 179229684 - AC007040.2 chr2 70939318 70995336 - AC010422.3 chr19 12643831 12648397 - AC011462.1 chr19 41350853 41425001 + AC011530.1 chr19 45779437 45785973 - AC091167.2 chr15 90249556 90272208 + AC092647.5 chr7 55887277 55955239 + ACACA chr17 37084992 37406836 - ACADVL chr17 7217125 7225266 + ACTB chr7 5527148 5563784 - ADAM11 chr17 44758988 44781846 + ADAM8 chr10 133262420 133276868 - ADARB1 chr21 45073853 45226560 + ADCK2 chr7 140672945 140696261 + ADGRE5 chr19 14380501 14408725 + ADGRG2 chrX 18989307 19122637 - AGAP1 chr2 235494043 236131800 + AGAP3 chr7 151085831 151144436 + AGPAT5 chr8 6708642 6761503 + AGRN chr1 1020120 1056118 + AL136295.4 chr14 24180395 24190416 - ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-4787-5p chr3 50675093 50675114 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006538.1 chr19 2727743 2729327 - AC011753.2 chr2 109594693 109605698 - AC084125.2 chr8 144495458 144505444 - AC109460.3 chr16 28974804 28990775 + AD000090.1 chr19 35557956 35581954 + AGAP11 chr10 86970741 87010126 + AL049796.1 chr1 93847174 93848939 + AL117379.1 chr20 62928621 62929297 - AL136982.1 chr10 86992406 87010203 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.