exRNAdisease

Entry Detail

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General Information

Database ID: exR0442708 RNA Name: TNRC6B RNA Type: mRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 40044817 End Site(bp): 40335808 External Links: ENSG00000100354

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.6 chr16 29812261 29820092 + ADCY6 chr12 48766194 48789037 - AHI1 chr6 135283532 135497765 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-let-7a-5p chr9 94175962 94175983 + hsa-let-7b-5p chr22 46113691 46113712 + hsa-let-7e-5p chr19 51692793 51692814 + hsa-miR-129-5p chr7 128207876 128207896 + hsa-miR-147a chr9 120244985 120245004 - hsa-miR-34a-5p chr1 9151735 9151756 - hsa-let-7g-5p chr3 52268336 52268357 - hsa-let-7i-5p chr12 62603691 62603712 + hsa-miR-140-5p chr16 69933103 69933124 + hsa-miR-142-3p chr17 58331245 58331267 - hsa-miR-185-5p chr22 20033153 20033174 + hsa-miR-206 chr6 52144401 52144422 + hsa-miR-200a-3p chr1 1167916 1167937 + hsa-miR-34c-5p chr11 111513451 111513473 + hsa-miR-449a chr5 55170586 55170607 - hsa-miR-613 chr12 12764709 12764728 + hsa-miR-449b-5p chr5 55170706 55170727 - hsa-miR-501-3p chrX 50009772 50009793 + hsa-miR-502-3p chrX 50014649 50014670 + hsa-miR-616-3p chr12 57519183 57519204 - hsa-miR-1286 chr22 20249145 20249165 - hsa-miR-1321 chrX 85835832 85835849 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.